Author(s):
1. Maria Savanović, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za fiziku, Serbia
2. Andrijana Bilić, 1Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu ž, Serbia
3. Stevan Armaković, Serbia
4. Milinko Perić, Univerzitet u Novom Sadu, Institut Biosens, Serbia
5. Svetlana Pelemiš, Faculty of Technology - University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
6. Sanja Armaković, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za fiziku, Serbia

Abstract:
The goal of validation is to provide an optimized method that provides reliable and accurate results. Optimization and validation of the Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method are highly significant to pharmacy, agriculture, biomedicine, etc. This method is used for qualitative and quantitative analysis and quality control. The main objective of this study was to optimize and validate a simple and rapid analytical method for isolating the active component metoprolol tartrate from commercial tablets. Parameters such as specificity/selectivity, sensitivity, linearity, dynamic range, detection limit, quantification limit, accuracy, precision, and robustness were determined. The practical application of the validated method was observed in the photodegradation study of metoprolol in the presence/absence of TiO2 Hombikat using simulated solar and UV irradiation.

Key words:
Method validation,TiO2,β-blocker

Thematic field:
SYMPOSIUM A - Science of matter, condensed matter and physics of solid states

Date of abstract submission:
26.07.2023.

Conference:
Contemporary Materials 2023 - Savremeni materijali

Abstract