Author(s):
1. Borko Matijević, Serbia
2. Gorana Mrđan, Prirodno-matematički fakultet u Novom Sadu, Serbia
3. Đenđi Vaštag, Serbia
4. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia
5. Isidora Nikolić, Serbia
6. Petar Knežević, Serbia

Abstract:
The resistance of microorganisms to antimicrobial agents known so far represents a global clinical and therapeutic problem. The loss of the drug's ability to kill bacteria or inhibit its reproduction forces scientists to find a new target of the drug's action or to synthesize new compounds to which microorganisms have not yet developed resistance. Many thiocarbohydrazone derivatives have been shown as good antimicrobial agents. Most of the tested thiocarbohydrazones so far belong to bisubstituted compounds, while monothiocarbohydrazones have been studied less, despite the fact that due to the free amino group, they can have greater biological activity than their bisubstituted analogs. In this work, the antimicrobial activity of eighteen previously synthesized and characterized monothiocarbohydrazone derivatives was tested using a modified microdilution method. The obtained results show that the studied derivatives act to a greater or lesser extent on Gram-positive bacteria, as well as that their activity depends on the type and position of the substituent present on the benzene ring.

Key words:
antimicrobial agents, biological activity, Gram-positive bacteria, microdilution method, monothiocarbohydrazones

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
20.07.2023.

Conference:
Contemporary Materials 2023 - Savremeni materijali

Applied paper from author