Author(s):
1. Branka Rodić Grabovac, Faculty of Technology Banja Luka, Republic of Srpska, Bosnia and Herzegovina
2. Radana Đuđić, Faculty of Technology Banja Luka, Republic of Srpska, Bosnia and Herzegovina
3. Pero Sailović, Faculty of Technology Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Abstract:
This paper investigates the effect of reaction conditions on oxidation of cellulosic fiber in form of bandage with the aim of obtaining material suitable for chemical binding of antibiotics . Also, the influence of structure of cefazoline on sorption on oxidized cellulosic fiber is investigated. The chemical bonding of the drug was performed on oxidized cellulose samples (OC) with different carboxylic groups content in ceftriaxone water solution concentration of c = 1.7 ∙ 10-3 mol / L , while the desorption of bonded antibiotic was done in the physiological solution. The amounts of bonded and released drug were determined by spectrophotometrically in UV range . Binding of ceftriaxone is achieved via chemical and physical bonds. It was found that carboxylic groups content on OC and solution pH during sorption process have significant influence on the amount of bonded antibiotics. The results of the conducted experiment indicate that the maximum amount of bound drug 23.33 mg/g and released 3.25 mg/g. Antimicrobial activity of fiber samples with bonded ceftriaxone were tested in vitro on microorganisms Staphylococcus aureus , Bacillus subtilis and Escherichia coli.

Key words:
biološki aktivni materijal, ceftriakson, oksidovana celuloza

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
29.05.2015.

Conference:
Contemporary Materials 2015 - Savremeni Materijali